NBDF funds a broad range of research programs that seek to increase our understanding of the science behind bleeding disorders, how they affect people's lives, and pathways to better treatments and cures.

Development of an Institution-Wide, Customizable, Computer-Based, Training Module

Development of an Institution-Wide, Customizable, Computer-Based, Training Module

Year:
-
Grants:
Nursing Excellence Fellowship
Author(s):
Robin Chapman
The purpose of this project is to request support for the development of a computer-based training (CBT) module designed to teach the care and treatment of patients with bleeding disorders to nursing staff in a large, multi-campus pediatric healthcare institution. The module will be designed to exist within an intranet environment accessed by all members of the healthcare institution. Core modules will include a description of each common bleeding disorder, a basic review of processes surrounding the multidisciplinary care of bleeding disorder patients, the involvement of other hospital departments in managing a patient with a bleeding treatment plan (e.g., blood bank, coagulation lab, hemophilia treatment center staff) and medications/factor products routinely used to treat them. The result, a custom-made bleeding disorder CBT, would be available at any time to any staff member on any of the institution's campuses being assigned to care for bleeding disorder patients, thus facilitating nursing education and patient care.
The Prevalence and Risk Factors for Depression in Adults with Hemophilia

The Prevalence and Risk Factors for Depression in Adults with Hemophilia

Year:
-
Grants:
Social Work Excellence Fellowship
Author(s):
Laurel Pennick, Maria Iannone
Despite the fact that adults with hemophilia fit the profile of a population at high risk for experiencing depression, not to mention the significant impact of depression on their overall well-being, there are almost no studies in the literature to document the incidence of depression for these patients. This study is designed to document the prevalence of depression in adults with hemophilia at our treatment center and to evaluate risk factors for depression in these patients as well as patients from Region VIII who have completed the Centers for Disease Control and Prevention's Quality of Life questionnaire. Evaluation of the information collected is expected to show that a significant percentage of adults with hemophilia are experiencing symptoms of depression. The Arizona Hemophilia and Thrombosis Center plans to use this information to apply for future funding to support the development of a depression care management plan, which will be incorporated into standard care.

Pharmacogenomics of Hemophilia Therapy: Genetics of Inhibitor Antibody Response

Year:
-
Grants:
Career Development Award
Inhibitors
Author(s):
Jay Lozier
Qizen Shi

Immune Response in Platelet-Derived FVIII Gene Therapy of Murine Hemophilia A

Year:
-
Grants:
Career Development Award
Gene Therapy
Hemophilia A (Factor VIII/F8)
Platelets
Author(s):
Qizhen Shi

Targeting Dendritic Cells to Induce Immune Tolerance to Factor VIII

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Inhibitors
Author(s):
Ruijin Su

Recombinant Factor VIIa and RL Platelets as a Hemophilia Therapy

Year:
-
Grants:
Career Development Award
Platelets
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Factor VII/F7
Author(s):
Alisa Wolberg

Proficient AAV Vectors for the Treatment of Hemophilia B (2007)

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia B (Factor IX/F9)
Gene Therapy
Author(s):
Jyoti Mathur
Junjiang_Sun

Hemophilic Arthropathy: Gene Delivery Vectors for Determining Mechanisms and Therapy

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Gene Therapy
Hemophilic Arthropathy
Pain
Author(s):
Jun-Jiang Sun

Illinois Amish Community Outreach Project

Year:
-
Grants:
Social Work Excellence Fellowship
Author(s):
Jenny Purdy
Our goal is to establish an outreach clinic in an area that will serve the Amish bleeding disorder community. After the completion of our formal project, we plan to continue to offer our services to the community to provide ongoing education, screening, and testing for individuals with bleeding symptoms or with a family history of a bleeding disorder. Furthermore, we plan to extend our clinical support to the other Amish communities located in downstate Illinois.

Self-Regulating HIV Vectors for Hemophilia A Gene Therapy

Year:
-
Grants:
Career Development Award
Gene Therapy
HIV/AIDS
Hemophilia A (Factor VIII/F8)
Author(s):
Yashuhiro Ikeda

Identification of Chemical Modifiers of Coagulation

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
David Buchner

A Disease-Specific DNA Chip for von Willebrand Disease

Year:
-
Grants:
Career Development Award
Von Willebrand Disease
Author(s):
Bradley E. Aouizerat

Platelets as Modifiers of Phenotype in Hemophilia A

Year:
-
Grants:
Career Development Award
Hemophilia A (Factor VIII/F8)
Platelets
Author(s):
Donald L. Yee

Proficient AAV Vectors for the Treatment of Hemophilia B (2005)

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia B (Factor IX/F9)
Gene Therapy
Author(s):
Michael Herbert

Transposon Mediated Gene Therapy of Hemophilia

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Gene Therapy
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Li Liu

Retroviral Vector-Mediated Neonatal Gene Therapy for Hemophilia A

Year:
-
Grants:
Career Development Award
Gene Therapy
Hemophilia A (Factor VIII/F8)
Author(s):
Lingfei Xu

Mechanism for the Ectopic Expression of Galgt2 in Endothelial Cells

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Von Willebrand Disease
Author(s):
Jill Marie Johnson

Individualized Phenotypic Prophylaxis for Hemophilia

Year:
-
Grants:
Career Development Award
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Kathleen Brummel-Ziedins

Development of Nanoparticles for Non-viral Hemophilia Gene Therapy

Year:
-
Grants:
Career Development Award
Gene Therapy
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Suzie Hwang Pun

Regulation of Factor V and VIII Secretion by an ER to Golgi Transport Receptor

Year:
-
Grants:
Career Development Award
Factor V
Hemophilia A (Factor VIII/F8)
Author(s):
Bin Zhang