NBDF funds a broad range of research programs that seek to increase our understanding of the science behind bleeding disorders, how they affect people's lives, and pathways to better treatments and cures.

Interaction of Factor VIII with Factor IXa

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Degang Zhong

Persistent Expression of Factor IX

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia B (Factor IX/F9)
Author(s):
David Bruce Schowalter

Gene Therapy for Hemophilia B

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Gene Therapy
Hemophilia B (Factor IX/F9)
Author(s):
Qicheng Yang
Scott_Tenenbaum

HIV Resistance in Hemophiliacs

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
HIV/AIDS
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Scott A. Tenenbaum

Per Dr. Tenenbaum, the JGP provided him with the necessary framework to complete his Postdoctoral Fellowship at Duke University Medical Center and his first academic position at SUNY, where he is currently a Professor specializing in RNA Nanotechnology and Genomics. Although he has not remained in the field of hematology, his current research does intersect with many diseases, including those in the field of hematology (and specifically, hemophilia). The intersection is in relation to gene therapy technology that he is developing.

Dwight_Koeberl

Factor VIII Gene Therapy Vectors

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Gene Therapy
Hemophilia A (Factor VIII/F8)
Author(s):
Dwight D. Koeberl

Factor VIII–Specific T Lymphocytes

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
HIV/AIDS
Author(s):
Sylvia T. Singer
Per Dr. Singer, the JGP greatly influenced her career in research. It allowed her to focus on a research project, understand the process of asking a question/creating a hypothesis and developing (with guidance) a research plan; as well as analyze the date, present it (at NHG meeting at ASH) and write/publish it. It sparked her interest in hematology and in clinical research. She has pursued her work in the field of Pediatric Hematology and has obtained funding for research (including a K23 award). She has continued with ‘benign hematology’, focusing on Thalassemia (clinical and clinical research), as well as general hematology and hemostasis. Recently, she has become more involved in hemostasis (clinical care and sponsored studies related to bleeding/thrombosis).

Gene Therapy for Hemophilia A and B

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Gene Therapy
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Theo Palmer
Athan_Kuliopulos

Vitamin K-Dependent Carboxylase (1991)

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Vitamin K
Author(s):
Athan Kuliopulos

Gene Therapy of Hemophilia B

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Gene Therapy
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Frederick K. Askari

Genetics of Type I/ III von Willebrand Disease

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Von Willebrand Disease
Author(s):
William C. Nichols

Replacement of the Factor IX Gene in a Canine Hemophilia B Model

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia B (Factor IX/F9)
Gene Therapy
Author(s):
Jay Nelson Lozier

Molecular and Cell Biology on von Willebrand Factor Variants

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Von Willebrand Disease
Author(s):
Jack C. Rayner

Carbohydrate and Carbohydrate Sulfation in the Structure and Function of von Willebrand Factor

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Von Willebrand Disease
Author(s):
Josephine A. Carew

Characterization of Gene Defects in Hemophilia A

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Gene Therapy
Author(s):
Monica D. Traystman
James_Evans

The Molecular Biology of Canine Hemophilia B

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia B (Factor IX/F9)
Author(s):
James P. Evans

von Willebrand Disease: Molecular Studies in the Porcine Model

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Von Willebrand Disease
Author(s):
Wadie Bahou
Michael_Katzman

Mechanisms of Retroviral Integration Recombination

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
HIV/AIDS
Author(s):
Michael Katzman

Per Dr. Katzman, the Judith Graham Pool Research Fellowship in Hemophilia from the National Hemophilia Foundation, that he received in 1986, was extremely formative. This initial support was the starting point that led to 25 years of productive research in HIV/AIDS, during which he believes he made significant contributions to understanding the mechanism of retrovirus integration (and the introduction of integrase inhibitors into clinical practice for treating HIV infection was particularly gratifying). The JGP Fellowship allowed him to transition during his Infectious Diseases Fellowship in a new direction. Having worked with Dr. Michael Lederman in the Department of Medicine at Case Western Reserve University and University Hospitals of Cleveland for two years on the immune dysfunction in HIV-infected hemophiliacs, this grant allowed him to enter the basic science laboratory of Jonathan Leis in the Department of Biochemistry, where he remained for 3 years in what — in essence — was a 5-year Fellowship in Infectious Diseases. Having gained this extra training, he was then prepared to obtain an independent faculty position and he moved to the Milton S. Hershey Medical Center and Penn State College of Medicine in the Departments of Medicine and Microbiology & Immunology in 1989. He continues in this faculty position, where he has combined basic research on retroviral integration with the clinical care of persons with HIV and other infectious Diseases, though he did close his basic science lab at the end of 2011. A description of his research and career record is available at: https://profiles.psu.edu/profiles/display/111718

The Role of Hepatitis B and Hepatitis Delta Virus as Cofactors in the Acquired Immunodeficiency Syndrome in a Hemophilia Population

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hepatitis/Liver Disease
HIV/AIDS
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Nancy Collins O’Brien

Studies in Fibrinolysis: Human Endothelial Cells in Culture and In Vivo Studies in Hemophilia

Modulation of Plasminogen Activator and Plasminogen Activator from Human Endothelial Cells

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Plasminogen Activator 1 (PA1)
Author(s):
Paula Silverman

DNA Analysis of the Factor IX Gene and the Role of B-Hydroxyaspartic Acid in the Vitamin K-Dependent Coagulation Factor

DNA Analysis of the Factor IX Gene from a Patient with Hemophilia B

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Vitamin K
Hemophilia B (Factor IX/F9)
Author(s):
Barbara G. Schach