Study Design of a Phase 3, Open-Label Trial of the Safety and Efficacy of Recombinant Factor IX Fc Fusion Protein for the Prevention and Treatment of Bleeding Episodes in Previously Untreated Patients With Severe Hemophilia B
Gingival Bleeding and Oral Hygiene in Women with von Willebrand Disease
Objectives: To determine the relationship between von Willebrand disease (vWD), dental plaque, and gingival bleeding in women with vWD and to determine the oral hygiene habits and dental care utilization in women with vWD.…
Safety and Effectiveness of Anti Inhibitor Coagulation Complex (AICC) in Routine Clinical Management: a Post-Authorization Safety Study (PASS)
Bleeding Risk for the Active Person with Hemophilia: A Comparison of Factor VIII Treatment Regimens
Background: Bleeding risk during physical activities for persons with hemophilia has been shown to be reduced with adequate factor levels (Broderick 2012). With extended half-life Factor VIII and IX products offering…
The Impact of Reduced Treatment Frequency: Qualitative Evaluation of Adherence and Outcomes in Chronic Disease Management
The expression of codon-optimized blood coagulation factor VIII using a lentiviral system
Using Oral History for Patient Education: The Gift of Experience II: Conversations with Parents about Hemophilia
New insights from modeling FVIII Kinetics of Native vs. Extended Half-life FVIII Products - Comparing FVIII Coverage under Various Dosing Scenarios
Introduction: Extended half-life factor VIII (FVIII) products currently in development require a careful evaluation of dosing options given that the pharmacokinetics of weekly FVIII levels , including FVIII peak and trough levels…
The use of combination therapy with plasma derived and recombinant factor VIII in patients with hemophilia A: a single institution experience
Ongoing Prospective ADVATE Immune Tolerance Induction Registry (PAIR) Continues to Demonstrate Success Rates Consistent with Published Literature
Objectives: PAIR is an ongoing, global, non-interventional, post-authorization safety surveillance designed to collect information on ADVATE safety and effectiveness in immune tolerance induction (ITI) therapy in routine practice…