Revisions: 264, 245, 197, 185, 172.BackgroundInherited bleeding disorders are under-recognized as a cause of excessive uterine bleeding since uterine bleeding is expected during menstruation and with pregnancy.…
Revisions: 224; 203; 200; 193; 234
Hepatitis C (HCV) is now the leading cause of mortality in individuals with hemophilia. The development and approval of direct-acting agents (DAAs) have revolutionized treatment. Recently the FDA has approved 2…
Revisions: 248; 214; 96Since the genes for factors VIII and IX were identified and sequenced in the 1980s, numerous gene changes have been identified in persons with hemophilia A and B. This information has led to increased…
Revisions: 251; 175; 252
Women with bleeding disorders are at risk for bleeding in the peripartum period. Women with bleeding disorders and female carriers of hemophilia may also have affected newborns who are at risk for bleeding at…
Revisions: 127; 212
The National Hemophilia Foundation (NHF) has recognized the importance of the development of gene transfer and stem cell research to cure bleeding disorders. To this end, NHF has supported collaborative relationships between…
Currently, adeno-associated virus (AAV) has been identified as the most efficient method to transfer new genes into individuals with a variety of monogenic diseases. Nearly 200 clinical studies have utilized this vector for a number of monogenic…
Revisions: 175, 252
MASAC Document #257
Replaces Doc #252
GUIDELINES FOR EMERGENCY DEPARTMENT MANAGEMENT OF INDIVIDUALS WITH HEMOPHILIA AND OTHER BLEEDING DISORDERS
…
Revisions: 255; 258
A. Introduction
Emicizumab is a recombinant, humanized, bispecific immunoglobulin G4 monoclonal antibody that substitutes for part of the cofactor function of activated factor VIII (FVIIIa) by bridging activated…
National Hemophilia Foundation Medical and Scientific Advisory Council (NHF MASAC)
Pain Initiative Task Force:
Tyler W. Buckner, MD, MSc1 (chair), Maria E. Santaella, RN-BC, MSN, CPHON2, Michelle L. Witkop, DNP, FNP-BC2, Thomas J. Humphries, MD…
Background:
The need for prophylaxis is expanding in persons with hemophilia (PWH) due to the relatively frequent use of endoscopy in general medical care of patients with gastrointestinal signs and symptoms and…