Intracranial hemorrhage in the neonate with a bleeding disorder can cause permanent disability or death, especially if it is unrecognized and untreated. The incidence of intracranial hemorrhage in neonates with congenital bleeding disorders is…
This material is provided for your general information only. NHF does not give medical advice or engage in the practice of medicine. NHF under no circumstances recommends particular treatment for specific individuals and in all…
Human plasma is required to correct the hemostatic defect in patients with rare hereditary coagulation deficiencies, such as factors I, II, V, VII, X, XI and XIII, for which specific therapeutic concentrates are not available. Plasma is also…
The National Hemophilia Foundation supports gene therapy as the most promising strategy for curing hemophilia. At this time, NHF also supports the position advocated in the Orkin-Motulsky report on gene therapy that gene therapy should be somatic…
Introduction
Creutzfeldt-Jakob disease (CJD) is a rare but fatal condition associated with a poorly understood transmissible agent that may arise from genetic mutations in the prion protein gene or may be contracted through…
Progressive joint destruction contributes major morbidity to persons with hemophilia. Currently, there are multiple approaches to prevent or ameliorate early joint inflammation (synovitis) including prophylaxis (regular replacement factor infusions…
MASAC supports participation in AIDS clinical trials by HIV-infected persons with hemophilia and other bleeding disorders. MASAC specifically supports the optimization of inclusion criteria to allow such individuals to participate in AIDS clinical…
CMV-seropositive blood donors may have peripheral blood mononuclear cells that are latently infected with CMV. Furthermore, a small proportion of CMV-seronegative individuals are CMV carriers who are able to transmit CMV through blood products for…
The National Hemophilia Foundation (NHF) supports the development of comprehensive outcome measures for the treatment of bleeding disorders and their complications, with the goal of improving the quality of care for individuals with congenital…
MASAC has received reports of individuals with bleeding disorders who have experienced difficulties receiving appropriate emergency medical care. To address this issue, MASAC recommends the following:
1. Individuals with bleeding disorders should…