HLA Alleles Associated with Inhibitor Development in Severe Hemophilia A: Analysis of the “My Life, Our Future” Hemophilia A Cohort

An analysis of the My Life, Our Future genetic database found that  people with severe hemophilia A who are Black or Hispanic had a higher  risk of developing inhibitors.  It also found that the risk of inhibitor  development was similar for all large mutations in the gene for the  factor VIII protein. The research team looked deeper—into HLA (human  leukocyte antigen) alleles—and found immune-related mechanisms that may  help explain why some people develop inhibitors and others do not.  Join  us for an in-depth exploration of this study.

Speakers:  Sara Contente, PhD; Anwar Ahmed, PhD; Kathleen Pratt, PhD; Mosi Williams, Phys.D; Moderator: Michael Recht, MD, PhD, MBA